Start out with a title slide that has the Journal Article name and Authors on it
Create an introduction that provides a broad perspective for the specific work being presented. For example, if you are presenting a paper on a new protein, you should provide some background on the protein family and what it does. Don't assume that everyone in your audience knows the background. You can use your own content if you like - along with that given by the authors.
Instead of simply describing the methods used, look at the methods critically, with an eye for anything interesting or unusual. Point out anything that might be generally useful. For example, did the authors use any techniques that we are currently using in our lab?
Include graphs and figures from the paper. You can also make your own cartoons and schematic diagrams or show relevant pictures to get across the point.
Make an effort to explain what is going on in the figures (you can leave out some if they do not contribute to a 10 minute presentation)
Be sure to actually show the images and figures from the paper when talking about them (include some type of caption)
Do the results suggest any additional experiments that would be the next step?
Feel free to interject your own viewpoint of the research (is it valuable, did they do anything you liked or disliked?)
Clearly explain the significance of the results. Results by themselves are dull, unless they have significance. The significance may not be obvious to the audience, so point it out specifically.
What is the most significant contribution of the specific work to the field in general?
Try to appear truly interested (even excited!) about the work you are presenting. Enthusiasm is contagious, and keeps your audience interested. Can you think of anything to make your presentation unique? An unusual prop or visual aid? Make your presentation "professional". That means, stand up in front, look directly at your audience, and don't "read" your slides.
Go through your talk at least once as a practice run
Upload your presentation before class to the GroupMeetingSlides/Journal Club folder on Google Docs
5th Papers
July 12th - Tuesday Jeanette Singh, J.; Chuaqui, C.; Boriack-Sjodin, P.; Lee, W.; Pontz, T.; Corbley, M.; Cheung, H.; Arduini, R.; Mead, J.; Newman, M.; Papadatos, J.; Bowes, S.; Josiah, S.; Ling, L., Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI). Bioorg Med Chem Lett 2003, 13 (24), 4355-9. SinghVirtualTGFbetaBioorgMedChemLett2003.pdf
Larry Herschhorn, A.; Hizi, A., Virtual screening, identification, and biochemical characterization of novel inhibitors of the reverse transcriptase of human immunodeficiency virus type-1. J Med Chem2008,51 (18), 5702-13. HerschhornHIVreversetranscriptaseVirtualScreenJMedChem2008.pdf
4th Papers
July 5th - Tuesday Krishna Mochalkin, I.; Miller, J.; Narasimhan, L.; Thanabal, V.; Erdman, P.; Cox, P.; Prasad, J.; Lightle, S.; Huband, M.; Stover, C., Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches. ACS Chem Biol 2009, 4 (6), 473-83. MochalkinVirtualScreeningBiotinCarboxylaseFASII_ACSCHemBiol2009.pdf
3rd Papers
June 28th - Tuesday Sadhana Bai, Y.; Monzingo, A.; Robertus, J., The X-ray structure of ricin A chain with a novel inhibitor. Arch Biochem Biophys2009,483 (1), 23-8.
Cho, Y.; Ioerger, T.; Sacchettini, J., Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening. J Med Chem2008,51 (19), 5984-92. ChoSacchettiniVirtualScreening_TB_HisG_JMedChem2008.pdf
2nd Papers
June 21st - Tuesday Joey
Park, H.; Kim, Y. J.; Hahn, J. S., A novel class of Hsp90 inhibitors isolated by structure-based virtual screening. Bioorganic & Medicinal Chemistry Letters2007,17 (22), 6345-6349. ParkHsp90drugVirtualScreenBioorgMedChemLett2007.pdf
1st Papers
June 14th - Tuesday Marshall
Zolli-Juran, M.; Cechetto, J. D.; Hartlen, R.; Daigle, D. M.; Brown, E. D., High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate. Bioorganic & Medicinal Chemistry Letters 2003, 13 (15), 2493-2496. Zolli_JuranDHFRbacteriaHTSBioorgMedChemLett2003.pdf
Guidelines:
Upload your presentation before class to the GroupMeetingSlides/Journal Club folder on Google Docs
Presentation Order:
1st Week: none
2nd Week: Justin & Marshall
3rd Week: J.C. & Joey
4th Week: Christina & Sadhana
5th Week: Krishna
6th Week: Jeanette, Larry
7th Week: Hong, Indra
8th Week: Joshua
9th Week: none
7th Paper:
July 26th - Joshua
Tomlinson, S.; Malmstrom, R.; Watowich, S., New approaches to structure-based discovery of dengue protease inhibitors. Infect Disord Drug Targets 2009, 9 (3), 327-43.
TomlinsonWatowichDengueVirusInfectiousDisordersDrugTargets2009.pdf
6th Papers:
July 19th -
Indra
Hirayama, K.; Aoki, S.; Nishikawa, K.; Matsumoto, T.; Wada, K., Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening. Bioorg Med Chem 2007, 15 (21),
6810-8.
VDS_UBL3_bioorgmedchem2007.pdf
Hong
Sacchettini, J.; Rubin, E.; Freundlich, J., Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis. Nat Rev Microbiol 2008, 6 (1), 41-52.
SacchettiniTuberculosis_DrugsVsBugsNatRevMicrobiol2008.pdf
5th Papers
July 12th - Tuesday
Jeanette
Singh, J.; Chuaqui, C.; Boriack-Sjodin, P.; Lee, W.; Pontz, T.; Corbley, M.; Cheung, H.; Arduini, R.; Mead, J.; Newman, M.; Papadatos, J.; Bowes, S.; Josiah, S.; Ling, L., Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI). Bioorg Med Chem Lett 2003, 13 (24), 4355-9.
SinghVirtualTGFbetaBioorgMedChemLett2003.pdf
Larry
Herschhorn, A.; Hizi, A., Virtual screening, identification, and biochemical characterization of novel inhibitors of the reverse transcriptase of human immunodeficiency virus type-1. J Med Chem 2008, 51 (18), 5702-13.
HerschhornHIVreversetranscriptaseVirtualScreenJMedChem2008.pdf
4th Papers
July 5th - Tuesday
Krishna
Mochalkin, I.; Miller, J.; Narasimhan, L.; Thanabal, V.; Erdman, P.; Cox, P.; Prasad, J.; Lightle, S.; Huband, M.; Stover, C., Discovery of antibacterial biotin carboxylase inhibitors by virtual screening and fragment-based approaches. ACS Chem Biol 2009, 4 (6), 473-83.
MochalkinVirtualScreeningBiotinCarboxylaseFASII_ACSCHemBiol2009.pdf
3rd Papers
June 28th - Tuesday
Sadhana
Bai, Y.; Monzingo, A.; Robertus, J., The X-ray structure of ricin A chain with a novel inhibitor. Arch Biochem Biophys 2009, 483 (1), 23-8.
BaiRicinVirtualScreenToxicon2010.pdf
Christina
Cho, Y.; Ioerger, T.; Sacchettini, J., Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening. J Med Chem 2008, 51 (19), 5984-92.
ChoSacchettiniVirtualScreening_TB_HisG_JMedChem2008.pdf
2nd Papers
June 21st - Tuesday
Joey
Park, H.; Kim, Y. J.; Hahn, J. S., A novel class of Hsp90 inhibitors isolated by structure-based virtual screening. Bioorganic & Medicinal Chemistry Letters 2007, 17 (22), 6345-6349.
ParkHsp90drugVirtualScreenBioorgMedChemLett2007.pdf
J.C.
Zhang, Y.; White, S.; Rock, C., Inhibiting bacterial fatty acid synthesis. J Biol Chem 2006, 281 (26), 17541-4.
FASII_review_jbc2006.pdf
1st Papers
June 14th - Tuesday
Marshall
Zolli-Juran, M.; Cechetto, J. D.; Hartlen, R.; Daigle, D. M.; Brown, E. D., High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate. Bioorganic & Medicinal Chemistry Letters 2003, 13 (15), 2493-2496.
Zolli_JuranDHFRbacteriaHTSBioorgMedChemLett2003.pdf
Justin
Prasannan, P.; Suliman, H. S.; Robertus, J. D., Kinetic analysis of site-directed mutants of methionine synthase from Candida albicans. Biochem Biophys Res Commun 2009, 382 (4), 730-4.
PrasannanPriya_MetSynthaseKinetic_RobertusBiochemBiophysResComm2009.pdf